3-(Dimethylamino)-1-(3-thienyl)propan-1-ol

CAS: 116817-84-6

Ref. 3D-ID58099

Product Information

• Name: 3-(Dimethylamino)-1-(3-thienyl)propan-1-ol
• Synonyms: a-[2-(Dimethylamino)ethyl]-3-thiophenemethanol, (S)-(+)-N,N-dimethyl-3-hydroxy-(2-thienyl)-propanamine, (S)-1-b-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane, 3-Thiophenemethanol, A-[2-(Dimethylamino)Ethyl]-, 3-Thiophenemethanol, A-[2-(Dimethylamino)Ethyl]-(9Ci), S(+)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)-1-Propanamine, S-(-)-N,N-Dimethyl-3-Hydroxy-2-Thienylpropanamine, α-[2-(Dimethylamino)ethyl]-3-thiophenemethanol

Description

3-(Dimethylamino)-1-(3-thienyl)propan-1-ol (DMAT) is an impurity that was identified in a drug product and that is not found in the natural form. DMAT is an intermediate of the synthesis of DMH, which is used as a research and development tool. DMAT has been shown to be metabolized by cytochrome P450 enzymes and other oxidative reactions, such as oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. DMAT also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

• Brand: Biosynth

Chemical properties

• Molecular weight: 185.29 g/mol
• Formula: C₉H₁₅NOS
• Purity: Min. 95%
• Color/Form: White to yellow solid.
• InChI: InChI=1S/C9H15NOS/c1-10(2)5-3-9(11)8-4-6-12-7-8/h4,6-7,9,11H,3,5H2,1-2H3
• InChI key: InChIKey=HKVIPLMMUMBSKB-UHFFFAOYSA-N
• SMILES: CN(C)CCC(O)c1ccsc1