Product Information
- 468: PN: WO2005081628 SEQID: 470 claimed protein
- <span class="text-smallcaps">L</smallcap>-Leucine, <smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl-
- <span class="text-smallcaps">L</smallcap>-Leucine, N-(1-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl)-
- <span class="text-smallcaps">L</smallcap>-Valyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-leucine
- H-Val-Pro-Leu-OH
- L-valyl-L-prolyl-L-leucine
- Valylprolylleucine
Diprotin B is a colony-stimulating factor protein that has inhibitory properties in the colon. It has been shown to be effective in reducing symptoms of bowel disease and inflammatory bowel disease, as well as reducing the recurrence of colon cancer. Diprotin B inhibits the release of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The inhibition of these proinflammatory cytokines may contribute to the anti-inflammatory effects observed with Diprotin B treatment. Diprotin B also prevents cytosolic calcium accumulation, which can lead to cell lysis. This process is mediated by antimicrobial peptides called defensins that are expressed in Paneth cells found in the small intestine and colon. Defensins have also been shown to induce cell lysis through their ability to bind to bacterial membranes.
Chemical properties
Technical inquiry about: 3D-IDB-3982-PI Diprotin B
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