11-Fluoro desloratadine
CAS: 298220-99-2
Ref. 3D-IF46257
| 1mg | 340.00 € | ||
| 2mg | 498.00 € | ||
| 5mg | 1,016.00 € | ||
| 10mg | 1,402.00 € |
Product Information
- Desloratadine impurity A8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with fluorinating reagent such as N-fluorosuccinimide (NFSI) in the presence of a base catalyst such as sodium methoxide. 11-Fluoro desloratadine is also found in breast milk at concentrations of up to 1.2% of total loratadine concentration, which has been attributed to incomplete metabolism or passive transfer from mother to child.
Chemical properties
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