Sitagliptin hydroxy amide impurity

CAS: 1253056-01-7

Ref. 3D-IS106472

Product Information

• Name: Sitagliptin hydroxy amide impurity
• Synonyms: 1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)-3-hydroxybutan-1-oneSitaglipti n impurity 13
• CAS: 1253056-01-7

Description

Sitagliptin is an oral dipeptidyl peptidase-4 inhibitor that is used to treat type 2 diabetes. It binds to the active site of the enzyme and reversibly blocks the action of the enzyme, thereby inhibiting the breakdown of a number of important hormones such as glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide. Sitagliptin hydroxy amide impurity is an impurity in sitagliptin that inhibits oxidoreductases, enzymes that catalyze oxidation reactions. The enantiomeric purity of sitagliptin hydroxy amide impurity is unknown.

• Brand: Biosynth

Chemical properties

• Molecular weight: 408.3 g/mol
• Formula: C₁₆H₁₄F₆N₄O₂
• Purity: Min. 95%
• InChI: InChI=1S/C16H14F6N4O2/c17-10-6-12(19)11(18)4-8(10)3-9(27)5-14(28)25-1-2-26-13(7-25)23-24-15(26)16(20,21)22/h4,6,9,27H,1-3,5,7H2
• InChI key: InChIKey=GUBAVYYUZMCLIR-UHFFFAOYSA-N
• SMILES: O=C(CC(O)Cc1cc(F)c(F)cc1F)N1CCn2c(nnc2C(F)(F)F)C1