Bretazenil

CAS: 84379-13-5

Ref. 3D-JDA37913

Product Information

• Name: Bretazenil
• Synonyms: 9H-Imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1-carboxylic acid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (S)-, 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (13aS)-, Bretazenil [USAN:INN], Bretazenilum, Bretazenilum [INN-Latin], Brn 4765855, Ro 16-6028, Ro 16-6028/000, Unii-Osz0E9Dgoj, tert-Butyl (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1-carboxylate, tert-butyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
• CAS: 84379-13-5

Description

Bretazenil is a benzodiazepine that binds to the GABA receptor. It is used as a sedative and an antidote for benzodiazepine overdoses. Bretazenil has been shown to have low potency, only binding to the α1 subunit of the GABA receptor. This drug also has a high affinity for δ receptors, which may be responsible for its locomotor effects and ability to reverse triazolam-induced amnesia. Chronic exposure to this drug can lead to tolerance, which may be due to the development of benzodiazepine or δ receptors. Bretazenil has been shown to have low potency in experimental models, but is still able to produce sedation in rats when given at doses of 0.01 mg/kg.

• Brand: Biosynth

Chemical properties

• Molecular weight: 418.28 g/mol
• Formula: C₁₉H₂₀BrN₃O₃
• Purity: Min. 95%