Product Information
- Urea, N-[1,4-dihydro-3-[4-[[4-(2-methoxyethyl)-1-piperazinyl]methyl]phenyl]-4-oxoindeno[1,2-c]pyrazol-5-yl]-N′-4-morpholinyl-
- 1-[3-[4-[[4-(2-Methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea
- N-[1,4-Dihydro-3-[4-[[4-(2-methoxyethyl)-1-piperazinyl]methyl]phenyl]-4-oxoindeno[1,2-c]pyrazol-5-yl]-N′-4-morpholinylurea
RGB-286638 is a potent antitumor agent that inhibits the activity of actin filaments. It has been shown to inhibit tumor growth in mice with cancer and to have minimal toxicity. The mechanism by which RGB-286638 exerts its antitumor effects is not fully understood, but it may be related to its ability to bind to the Mcl-1 protein and inhibit the function of this protein. RGB-286638 also binds to DNA and inhibits enzymatic activity necessary for cellular proliferation. This drug has been shown to produce necrotic cell death in vitro with minimal effect on healthy cells.
Chemical properties
Technical inquiry about: 3D-JGB21088 RGB-286638 free base
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