Product Information
Smad3 is a member of the TGF-β receptor family. It is a potent inhibitor of differentiation, proliferation, and apoptosis. Smad3 binds to the TGF-β type II receptor (TβRII) and then migrates into the nucleus to form a complex with SMAD4. This complex activates transcription of downstream genes that inhibit cell cycle progression, stimulate cell differentiation and inhibit apoptosis.
Smad3 has been shown to interact with the following proteins:
-GST tagged human
-p53
-p21waf1/cip1
-Bcl2
-Mdm2
-IκBα
Chemical properties
Technical inquiry about: 3D-JHA37952 Smad3, gst tagged human
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