(7S,9S)-9-Acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

CAS: 60660-75-5

Ref. 3D-KCA66075

Product Information

• Name: (7S,9S)-9-Acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione
• Synonyms: (7S,9S)9-Acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-5,12-naphtacenedione, 4-Demethoxydaunomycinone, Idarubicin aglycone, 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S,9S)-, 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S-cis)-, (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione
• CAS: 60660-75-5

Description

Acetylated analogues of homophthalic acid are a class of chemical compounds that have been studied for use in cancer treatment. The 9-acetyl derivative, (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione (AICAR), is a potent inhibitor of the enzyme protein kinase B and has been shown to inhibit the growth of cancer cells. AICAR has also been shown to induce insulin resistance and metabolic disorders in animal models. These effects may be due to its ability to inhibit mitochondrial ATP production and mitochondrial membrane potential.

• Brand: Biosynth

Chemical properties

• Molecular weight: 368.34 g/mol
• Formula: C₂₀H₁₆O₇
• Purity: Min. 95%