Domatinostat
CAS: 910462-43-0
Ref. 3D-KLB46243
| 5mg | To inquire | |
| 10mg | To inquire | |
| 25mg | To inquire | |
| 50mg | To inquire | |
| 100mg | To inquire |
Product Information
Domatinostat is a retinoid-related all-trans retinoic acid (ATRA) derivative. It is a low-molecular weight, water soluble molecule that can penetrate the cytosol of cells, where it binds to the retinoic acid receptor and inhibits cell growth. Domatinostat has been shown to be effective against prostate cancer cells in vitro and in animal models. This drug also shows cytostatic effects on fetal bovine kidney cells and is able to inhibit tumor growth in mice with skin cancer. Domatinostat induces apoptosis by inhibiting the phosphorylation of Akt and ERK1/2, which are proteins involved in regulating cell survival and proliferation pathways. Domatinostat has also been shown to be effective against urothelial carcinoma cells as well as bone cancer cells in vitro and in mice models.
Chemical properties
Technical inquiry about: 3D-KLB46243 Domatinostat
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