3-Aminoquinoxaline-2-carbonitrile
CAS: 36597-16-7
Ref. 3D-LBA59716
1g | Discontinued | ||
5g | Discontinued | ||
100mg | Discontinued | ||
250mg | Discontinued | ||
500mg | Discontinued |
Product Information
3-Aminoquinoxaline-2-carbonitrile (3AQC) is a photochemically active compound that has been shown to be cytotoxic against V79 cells and other cell lines in vitro. 3AQC binds to intracellular fatty acids, such as palmitic acid, and reacts with the n-oxide group to form a reactive chlorine atom. This chlorine atom can react with DNA to form crosslinks or cause single-strand breaks. These genotoxic effects lead to inhibition of glycolysis and protein synthesis, which leads to cell death. 3AQC also has a bioreductive effect on solid tumours due to its ability to generate free radicals from chlorinated lipids.