(2R, 3R, 4R, 5S) -3, 4- Dihydroxy- 5- (hydroxymethyl) - N- methyl-2- pyrrolidinecarboxami de
CAS: 1591782-91-0
Ref. 3D-MD163560
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Product Information
Methylation of a saccharide with a methyl group is called methylation. The process is used in the synthesis of many important molecules, including biomedically-relevant compounds such as drugs and natural products. Methylation can be achieved by using various methods, such as by using an organometallic (e.g., Grignard reagent) or electrophilic reagent (e.g., dimethyl sulfate).
In the present invention, the methyl group is added to a saccharide through an alkylation reaction with a methylating agent and a base catalyst, which are typically sodium methoxide or potassium t-butoxide. The 2R, 3R, 4R, 5S stereoisomer of this compound is synthesized in high yield via click modification with 1-iodo-2-pyrrolidinone and ammonium chloride in methanol at room temperature. This compound is then fluorinated to provide the desired product containing
Chemical properties
Technical inquiry about: 3D-MD163560 (2R, 3R, 4R, 5S) -3, 4- Dihydroxy- 5- (hydroxymethyl) - N- methyl-2- pyrrolidinecarboxami de
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