Product Information
RU.521 is a novel cytosolic inhibitor of autophagy that has been shown to activate the innate immune response and promote chronic pulmonary inflammation in animal models. The molecule binds to toll-like receptor 4 (TLR4) on human macrophages and elicits the release of tumor necrosis factor alpha (TNFα), IL-1β, and IL-6, which are proinflammatory cytokines that promote the activation of dendritic cells. This compound also induces polymerase chain reaction (PCR)-amplified mRNA transcripts encoding TLR4 in primary cells. RU.521 is also able to stop neuronal death in experimental models of Parkinson's disease by restoring mitochondrial function and inhibiting caspase 3 activation.
Chemical properties
Technical inquiry about: 3D-MQD45206 RU.521
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