Tri-b-GalNAc-6-aminohexanoate
Ref. 3D-MT184237
| 1mg | 1,218.00 € |
Product Information
- Tris-GalNAc-(CH2)6-NH2Triantennary β-GalNAc 6-aminohexanoatetri-beta-GalNAc-6-ACATris-GalNAc-Ahx-NH2Tris-β-GalNAc-6-aminohexanoi c acid
Tri-b-GalNAc-6-aminohexanoate is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.
Chemical properties
Technical inquiry about: 3D-MT184237 Tri-b-GalNAc-6-aminohexanoate
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