6-Amino-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)purine

CAS: 110143-10-7

Ref. 3D-NA05179

Product Information

• Name: 6-Amino-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)purine
• Synonyms: [(2S,4S,5R)-5-(6-Aminopurin-9-yl)-4-fluorooxolan-2-yl]methanolLodenosine, 2′-β-Fluoro-2′,3′-dideoxyadenosine, 9-(2,3-Dideoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-threo-pentofuranosyl)-9H-purin-6-amine, 9-(2,3-Dideoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-threo-pentofuranosyl)adenine, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)-9H-purin-6-amine, 9-(2,3-dideoxy-2-fluoropentofuranosyl)-9H-purin-6-amine, 9H-Purin-6-amine, 9-(2,3-dideoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-threo-pentofuranosyl)-, F-ddA, Lodenosine, Lodensine, NSC 613792, 9H-Purin-6-amine, 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-, 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine, 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-9H-purin-6-amine

Description

6-Amino-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)purine is a nucleoside analog that is used to treat HIV. It is a prodrug that undergoes phosphorylation by host cell kinases to form its active form, 2'-deoxycytidine monophosphate (2'DCPM). This drug has been shown to inhibit the replication of HIV in vitro and in vivo. 6-Amino-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)purine has antiviral potency against both group M and N HIV isolates. It also enhances polymerase chain reaction amplification of HIV DNA and can be used in tissue culture experiments to study the effects of drugs on the virus. Clinical trials have shown that 6-amino 9-(2',3'-dideoxy-2

• Brand: Biosynth

Chemical properties

• Molecular weight: 253.24 g/mol
• Formula: C₁₀H₁₂FN₅O₂
• Purity: Min. 95%
• Color/Form: White Powder