5'-Amino-5'-deoxyguanosine
CAS: 4099-84-7
Ref. 3D-NA16031
| 2mg | 273.00 € | ||
| 5mg | 522.00 € | ||
| 10mg | 959.00 € | ||
| 25mg | 1,823.00 € | ||
| 50mg | 3,403.00 € |
Product Information
- 2H-purin-6-ol, 9-(5-amino-5-deoxypentofuranosyl)-3,9-dihydro-2-imino-
5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.
The reaction mechanism for this reaction includes two steps: a substitution step and a ligation step. In
Chemical properties
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