Product Information
- 1-Amino-3-benzylthiourea
- 3-Amino-1-benzylthiourea
- 4-Benzylhydrazinethiocarbamide
- 4-Benzylthiosemicarbazide
- B 1308
- Hydrazinecarbothioamide, N-(phenylmethyl)-
- N-(Phenylmethyl)hydrazinecarbothioamide
- N-Benzylthiosemicarbazide
- N-benzylhydrazinecarbothioamide
- NSC 263514
- See more synonyms
- Semicarbazide, 4-benzyl-3-thio-
4-Benzyl-3-thiosemicarbazide is a postulated compound that has been shown to inhibit topoisomerase I and II. The inhibition of these enzymes leads to the prevention of DNA replication, repair, and transcription. 4-Benzyl-3-thiosemicarbazide has also been shown to be an anti-cancer agent by inhibiting the growth of tumor cells in vitro. It is thought that this drug may work by binding to the bidentate ligand on topoisomerase I and II, preventing them from cleaving dsDNA. Alternatively, it may work through an intramolecular hydrogen bond or an intermolecular hydrogen bond with the thiol group on the sulfur atom.
4-Benzyl-3-thiosemicarbazide is soluble in water and ethanol but insoluble in ether. It has been shown to have a melting point between 108°C and 111°C, with
Chemical properties
Technical inquiry about: 3D-NAA43141 4-Benzyl-3-thiosemicarbazide
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