4-Benzyl-3-thiosemicarbazide

CAS: 13431-41-9

Ref. 3D-NAA43141

Product Information

• Name: 4-Benzyl-3-thiosemicarbazide
• Synonyms: 1-Amino-3-benzylthiourea, 3-Amino-1-benzylthiourea, 4-Benzylhydrazinethiocarbamide, 4-Benzylthiosemicarbazide, B 1308, Hydrazinecarbothioamide, N-(phenylmethyl)-, N-(Phenylmethyl)hydrazinecarbothioamide, N-Benzylthiosemicarbazide, N-benzylhydrazinecarbothioamide, NSC 263514, Semicarbazide, 4-benzyl-3-thio-
• CAS: 13431-41-9

Description

4-Benzyl-3-thiosemicarbazide is a postulated compound that has been shown to inhibit topoisomerase I and II. The inhibition of these enzymes leads to the prevention of DNA replication, repair, and transcription. 4-Benzyl-3-thiosemicarbazide has also been shown to be an anti-cancer agent by inhibiting the growth of tumor cells in vitro. It is thought that this drug may work by binding to the bidentate ligand on topoisomerase I and II, preventing them from cleaving dsDNA. Alternatively, it may work through an intramolecular hydrogen bond or an intermolecular hydrogen bond with the thiol group on the sulfur atom.
4-Benzyl-3-thiosemicarbazide is soluble in water and ethanol but insoluble in ether. It has been shown to have a melting point between 108°C and 111°C, with

• Brand: Biosynth

Chemical properties

• Molecular weight: 181.26 g/mol
• Formula: C₈H₁₁N₃S
• Purity: Min. 95%