Ethyl (4-chlorophenyl)(hydroxy)acetate
CAS: 13511-29-0
Ref. 3D-NAA51129
| 1g | 922.00 € | ||
| 5g | 2,785.00 € | ||
| 100mg | 240.00 € | ||
| 250mg | 426.00 € | ||
| 500mg | 598.00 € |
Product Information
Ethyl (4-chlorophenyl)(hydroxy)acetate is a chiral, enantioselective, catalytic, and efficient synthetic reagent for the arylation of ketones. It has been used as an intermediate in the synthesis of various pharmaceuticals. This compound is prepared by reacting ethyl 4-chloroacetate with hydroxylamine and glyoxal in the presence of an acidic catalyst. The reaction proceeds via a phosphonium salt that acts as both a catalyst and an enolate trapping agent. This process results in high yield and selectivity for the desired product. A mutant of this compound has been developed that contains phosphite groups instead of chlorides to avoid potential side reactions with metal catalysts.
Chemical properties
Technical inquiry about: 3D-NAA51129 Ethyl (4-chlorophenyl)(hydroxy)acetate
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