Product Information
- Tetrazole-5-carboxylic-acid ethyl ester
- ethyl 2H-tetrazol-5-ylacetate
- 5-ethyl acetate Tetrazole
- ethyl 2-(2H-tetrazol-5-yl)acetate
Ethyl 1H-tetrazole-5-acetate (ETZA) is a ligand that binds to the active site of prolyl hydroxylase, which is an enzyme involved in collagen synthesis. ETZA inhibits the activity of this enzyme by binding to its heme cofactor, leading to a decrease in the production of collagen and thus inhibiting tumor growth. It has been shown that ETZA has no effect on healthy cells or normal tissues. In vitro studies have shown that ETZA can inhibit cancer cell growth and cisplatin resistance in vivo. ETZA also has a structural similarity to chloride ions and thus may be able to inhibit chloride channels such as those found in cancer cells.
Chemical properties
Technical inquiry about: 3D-NAA61637 Ethyl 1H-tetrazole-5-acetate
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