5'-O-tert-Butyldimethylsilyl-2'-deoxyuridine
Ref. 3D-NB08646
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Product Information
5'-O-tert-Butyldimethylsilyl-2'-deoxyuridine (5'-O-TBDMSU) is a modified nucleoside that has antiviral, anticancer and novel activities. It is synthesized by the reaction of 5'-O-tert-butyldimethylsilyl-2'-deoxyuridine with methyl chloroformate. 5'-O-TBDMSU has been shown to inhibit viral replication in cell culture. The antiviral activity of 5'-O-TBDMSU may be due to its ability to inhibit DNA synthesis by inhibiting the incorporation of deoxyribonucleotide triphosphates into DNA or by inhibiting the activity of DNA polymerases. This compound also inhibits the replication of RNA viruses such as HIV and hepatitis C virus, which are dependent on deoxyribonucleosides for their replication.
Chemical properties
Technical inquiry about: 3D-NB08646 5'-O-tert-Butyldimethylsilyl-2'-deoxyuridine
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