6-O-Benzyl-2'-deoxyguanosine
CAS: 129732-90-7
Ref. 3D-NB16627
| 5mg | To inquire | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Product Information
- 2'-Deoxy-6-O-(phenylmethyl)guanosine
- O6-B-dG
- Guanosine, 2'-deoxy-6-O-(phenylmethyl)-
- 6-(benzyloxy)-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-2-amine
- O(6)-Benzyl-2'-deoxyguanosine
6-O-Benzyl-2'-deoxyguanosine is a synthetic nucleoside analog that inhibits the synthesis of DNA. It is used in animal studies as a pancreatic carcinogen, and has been shown to inhibit tumor growth in mice. This drug specifically binds to DNA at the O6 position of guanine and methylates the adjacent cytosine residue, thereby preventing synthesis of DNA. 6-O-Benzyl-2'-deoxyguanosine also inhibits the activity of an enzyme called methyltransferase, which converts S-adenosylmethionine into S-adenosylhomocysteine, an intermediate in one of the pathways that produce methionine from homocysteine. This inhibition leads to an accumulation of methionine and its metabolites, including homocysteine and cystathione beta synthase, which can cause cell death.
Chemical properties
Technical inquiry about: 3D-NB16627 6-O-Benzyl-2'-deoxyguanosine
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