5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine

CAS: 141018-26-0

Ref. 3D-NC05725

Product Information

• Name: 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine
• Synonyms: 2-Iodoadenosine 5'-carboxy-2',3'-acetonide2-Iodo-9-(2,3-O-isopropylidene-b-D-ribofuranosyl uronic acid)adenine5'-Carboxy-2-iodo-2' ,3'-O-isopropylidene-D-adenosine
• Brand: Biosynth
• Description: 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine is an antiviral and anticancer monophosphate nucleoside. It has been shown to be a potent inhibitor of HIV replication in vitro, with IC50 values of 0.5 μM for HIV-1 and 0.8 μM for HIV-2. 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine also inhibits the replication of herpes simplex virus type 1 (IC50 = 0.7 μM) and cytomegalovirus (IC50 = 2.6 μM). 5'-Carboxy-2-iodo-2',3'-O-isopropylideneadenosine was found to be more than 10 times as potent as adenosine in inhibiting DNA synthesis in human tumor cell lines, including leukemia cells, carcinoma cells,

Chemical properties

• Molecular weight: 447.19 g/mol
• Formula: C₁₃H₁₄IN₅O₅
• Purity: Min. 95%