6-Chloro-9-(b-D-ribofuranosyl)purine

CAS: 5399-87-1

Ref. 3D-NC06562

Product Information

• Name: 6-Chloro-9-(b-D-ribofuranosyl)purine
• Synonyms: 6-Chloropurine riboside6-Chloro-6-deoxyinosine6-Chloro-9-(beta-D-ribofuranosyl)purine2,3,5-Tri-O-acetyl-6-chloropurine-9-beta-D-r ibofuranose, 6-Chloro-6-deaminoadenosine, 6-Chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-9H-purine, 6-Chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosylpurine, 6-Chloronebularine, 6-Chloropurine 9-β-<span class="text-smallcaps">D</span>-ribofuranoside, 6-Chloropurine nucleoside, 6-Chloropurine ribose, 6-Chloropurine-9-¤-D-ribofuranoside, 6-Chloropurine-<span class="text-smallcaps">D</span>-riboside, 6-Chloropurinosine, 6-chloro-9-(beta-D-ribofuranosyl)-9H-purine, 6-chloro-9-alpha-L-lyxofuranosyl-9H-purine, 6-chloro-9-pentofuranosyl-9H-purine, 9-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-6-chloropurine, 9H-Purine, 6-chloro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, NSC 4910
• CAS: 5399-87-1

Description

6-Chloro-9-(b-D-ribofuranosyl)purine is a purine analog that inhibits the synthesis of DNA, RNA, and protein. It has been shown to have physiological effects in cells, and it has been used as a positive control for enzyme activity studies. 6-Chloro-9-(b-D-ribofuranosyl)purine binds to an enzyme called hydroxymethylbilane synthase (HMBS), which inhibits the production of a molecule called tetrahydrobiopterin (THB). THB is essential for the synthesis of nitric oxide (NO), an important neurotransmitter that regulates neuronal death. 6-Chloro-9-(b-D-ribofuranosyl)purine also has significant cytotoxicity against melanoma cells in vitro.

• Brand: Biosynth

Chemical properties

• Molecular weight: 286.68 g/mol
• Formula: C₁₀H₁₁ClN₄O₄
• Purity: Min. 96 Area-%
• Color/Form: Powder