2'-Deoxyuridine-5'-monophosphate disodium salt

CAS: 42155-08-8

Ref. 3D-ND02992

Product Information

• Name: 2'-Deoxyuridine-5'-monophosphate disodium salt
• Synonyms: 5'-dUMP Na2, 2'-Deoxy-5'-Uridylic Acid, 2'-Deoxyuridine-5'-monophosphate,disodium salt, 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-5-O-phosphonopentofuranosyl)-, monosodium salt, 2-Deoxyuridine-5-triphosphoric acid disodium salt, 2′-Deoxyuridine 5′-phosphate disodium salt, 5′-Uridylic acid, 2′-deoxy-, disodium salt, 5′-Uridylic acid, 2′-deoxy-, sodium salt (1:2), Deoxyuridine 5′-monophosphate disodium salt, Disodium deoxyuridylate, dUMP.Na2, dUTP-Na2
• CAS: 42155-08-8

Description

2'-Deoxyuridine-5'-monophosphate disodium salt (2DUMP) is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase. 2DUMP is a covalent inhibitor of thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. This compound has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2DUMP is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus. It has been shown to bind to benzalkonium chloride (BAK) in biological samples such as serum or plasma.
2DUMP binds to BAK through a covalent linkage between the 3' hydroxyl group on BAK and the phosphate group on 2DUMP

• Brand: Biosynth

Chemical properties

• Molecular weight: 352.15 g/mol
• Formula: C₉H₁₁N₂O₈PNa₂
• Purity: Min. 95%
• Color/Form: Powder