2'-Deoxyadenosine-5'-monophosphate free acid

CAS: 653-63-4

Ref. 3D-ND05971

Product Information

• Name: 2'-Deoxyadenosine-5'-monophosphate free acid
• Synonyms: 5'-dAMP free acid2'-Deoxy-D-adenosine-5'-monophosphate free acid, 2'-Deoxy-5'-O-phosphonatoadenosine, 2'-Deoxyadenosine 5'-monophosphate, 2'-deoxy-Adenosine 5'-phosphorate, 5'-Adenylic Acid, 2'-Deoxy-, Ion(2-), dAMP.H2, 2'-Deoxyadenosine 5'-Phosphate, 2'-Deoxy-5'-adenylic acid, 2'-Deoxy-5'-AMP, 2'-Deoxyadenosine monophosphate, 2'-Deoxyadenylic acid, 2'-Deoxy-AMP, 2'-Desoxyadenosin-5'-(dihydrogenphosphat), 5'-Adenylic acid, 2'-deoxy-, 5'-dAMP, 5'-Dihidrogenofosfato De 2'-Desoxiadenosina, 5'-Dihydrogenophosphate De 2'-Desoxyadenosine, Adenosine, 2'-deoxy-, 5'-(dihydrogen phosphate), dAMP, Deoxyadenosine 5'-monophosphate, Deoxyadenosine 5'-phosphate, Deoxyadenosine monophosphate, Deoxyadenylic acid, Deoxy-AMP, Nsc 77680, Nsc 82625, PdA

Description

2'-Deoxyadenosine-5'-monophosphate free acid (2DAMP) is a nucleoside analogue that can be used as a fluorescent probe for detecting water vapor. 2DAMP has been shown to have cytotoxic activity against solid tumours in vitro, and may act by hydrogen bonding interactions with the active site of the enzyme form. 2DAMP is also an important cofactor in the polymerase chain reaction, and can inhibit cellular proliferation by inhibiting nuclear DNA synthesis. This drug has been used as an active antiretroviral therapy, where it inhibits HIV-1 reverse transcriptase. 2DAMP's mechanism of action involves the inhibition of p-nitrophenyl phosphate reductase (PNPPR), which is responsible for converting p-nitrophenyl phosphate into p-nitrophenol.

• Brand: Biosynth

Chemical properties

• Molecular weight: 331.23 g/mol
• Formula: C₁₀H₁₄N₅O₆P
• Purity: Min. 95%
• Color/Form: White Powder