1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil

CAS: 69123-98-4

Ref. 3D-ND08477

Product Information

• Name: 1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil
• Synonyms: Fialuridine, 1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil, 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione, 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil, 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione, 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione, 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-arabinofuranosyl)-5-iodouracil, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, 1-(2-deoxy-2-fluoropentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione, 1-[(2R,3S,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Iodopyrimidine-2,4-Dione, 2'-Fluoro-5-Iodo-2'-Deoxyuridine, 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-arabinofuranosyl)-5-iodo-, 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-, 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-, 5-Iodo-2'-fluoro-2'-deoxy-ara-uridine, 5-Iodo-2'-fluoro-deoxyuridine, 5-Iodo-2'-fluoroarauracil, Fluoroiodoarauracil, NSC 678514

Description

1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil is a prodrug that is converted to 5-iodouracil in the body. This drug is used to treat infectious diseases, such as leishmaniasis and Mycobacterium tuberculosis. 1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil inhibits mitochondrial functions by interfering with the synthesis of nucleotides and proteins. It also inhibits protein synthesis by inhibiting ribosomal function, leading to cell death. This drug has been shown to be effective against hepatocyte-like cells in vitro and in animal models.

• Brand: Biosynth

Chemical properties

• Molecular weight: 372.09 g/mol
• Formula: C₉H₁₀FIN₂O₅
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder