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Product Information
- 3H-pyrrolo[2,3-d]pyrimidine
- Pyrrolo(2,3-d)pyrimidine
- 1H-Pyrrolo[2,3-d]pyrimidine
- Deazapurine
7H-Pyrrolo[2,3d]pyrimidine is a pyrimidine compound that has been shown to have potent antitumor activity. It inhibits the enzyme acyl-coenzyme A carboxylase (ACC) and blocks the production of malonyl-CoA, an intermediate in the metabolism of fatty acids. Malonyl-CoA is an allosteric activator of ACC, which is an important enzyme for regulating fatty acid synthesis. 7H-Pyrrolo[2,3d]pyrimidine also inhibits the expression of the gene encoding cb2 receptor, which is involved in inflammatory processes. The compound binds to a hydroxyl group on ACC to inhibit its activity. 7H-Pyrrolo[2,3d]pyrimidine has been shown to be effective against miapaca-2 cells and other cancer cell lines at concentrations as low as 1 nM. This compound also has a
Chemical properties
Technical inquiry about: 3D-NP32608 7H-Pyrrolo[2,3d]pyrimidine
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