Monosialoganglioside GM1

CAS: 37758-47-7

Ref. 3D-OG03918

Product Information

• Name: Monosialoganglioside GM1
• Synonyms: Gal(b1-3)GalNAc(b1-4)[Neu5Ac(a2-3)]Gal(b1-4)Glc(b1-1)CersMonosialoganglioside GM1prototype gangliosidemonosialotetrahexosylgangli oside, G_M1, G_M1-Ganglioside, GM1, GM1-Ganglioside, Ganglioside A2, Ganglioside A₂, Ganglioside G4, Ganglioside G₄, Ganglioside G_Gtet1, Ganglioside G_I, Ganglioside G_M1, Ganglioside G_M1a, Ganglioside GGtet1, Ganglioside GI, Ganglioside GM1a, Ganglioside M1, Ganglioside M₁, Monosialotetrahexosylganglioside, Sialosylganglio-N-tetraosylceramide, Sygen, GangliosideGI, Ganglioside GM1, GangliosideG4 (7CI)

Description

GM1 (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009), and is abundant in all mammalian brains, where it covers 10%–20% of the total ganglioside mixture. GM1 is found in epithelial membranes and is a key element for the detection of bacterial toxicity and viral infection. It is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin (LTB) from E.coli, for rotavirus, and simian virus 40. GM1 functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,546.82 g/mol
• Formula: C₇₃H₁₃₁N₃O₃₁·xNa
• Purity: Min. 95 Area-%
• Color/Form: White Powder