GM3-Ganglioside sodium
CAS: 54827-14-4
Ref. 3D-OG16188
| 1mg | 346.00 € | ||
| 2mg | 542.00 € | ||
| 5mg | 1,113.00 € | ||
| 10mg | 2,105.00 € |
Product Information
- aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer
- G<sub>Lac1</sub>
- G<sub>M3</sub>
- GLac1
- GM3
- Ganglioside G<sub>M3</sub>
- Ganglioside M3
- Ganglioside M<sub>3</sub>
- Gangliosides, GM3
- Hematoside
- See more synonyms
- Monosialodihexosylganglioside
- Sialosyllactosylceramide
Ganglioside GM3 (sodium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as: lung, brain and melanomas, where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function and immune disorders (e.g., allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).
Chemical properties
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