GM1-Ganglioside labelled by biotin
Ref. 3D-OG31354
| 1g | To inquire | |
| 500µg | To inquire |
Product Information
- N-Hexanoyl-biotin-monosialoganglioside GM1
GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimerâs pathogenesis (Chiricozzi, 2020).
Chemical properties
Technical inquiry about: 3D-OG31354 GM1-Ganglioside labelled by biotin
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