GM1-Pentasaccharide labelled by biotin
Ref. 3D-OP31185
| 1mg | 1,821.00 € | ||
| 100µg | 355.00 € | ||
| 250µg | 677.00 € | ||
| 500µg | 1,012.00 € |
Product Information
- GM1-Pentasaccharide-O(CH2)3NHCO(CH2)5NH-biotin
GM1 pentasaccharide biotin (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue and biotin linked β to position 1 on the reducing glucose moiety (Ledeen, 2009). The parent ganglioside GM1 is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for cholera toxin the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimerâs pathogenesis (Chiricozzi, 2020).
Chemical properties
Technical inquiry about: 3D-OP31185 GM1-Pentasaccharide labelled by biotin
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