Dichloro(ethylenediamine)platinum(II)

CAS: 14096-51-6

Ref. 3D-PAA09651

Product Information

• Name: Dichloro(ethylenediamine)platinum(II)
• Synonyms: (SP-4-2)-Dichloro(1,2-ethanediamine-κN¹,κN²)platinum, Cpa 3, Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Dichloro(ethane-1,2-diamine)platinum(II), Dichloroplatinum(2+) Ethane-1,2-Diyldiazanide, Enplatin, NSC 125181, Platinum ethylenediamine dichloride, Platinum(2+) Dichloride - Ethane-1,2-Diamine (1:1), Platinum, dichloro(1,2-ethanediamine-N,N′)-, (SP-4-2)-, Platinum, dichloro(1,2-ethanediamine-κN,κN′)-, (SP-4-2)-, Platinum, dichloro(1,2-ethanediamine-κN¹,κN²)-, (SP-4-2)-, Platinum, dichloro(ethylenediamine)-, cis-Dichloro ethylenediammine platinum, cis-Dichloro(ethylenediamine)platinum, cis-Dichloro(ethylenediamine)platinum(Ⅱ)

Description

Dichloro(ethylenediamine)platinum (II) is a platinum-based anticancer drug that is used in the treatment of ovarian cancer. It binds to the phosphate group of DNA and forms a chelate ring with the DNA. This inhibits the cellular function of the DNA, preventing replication and transcription. The dichloro(ethylenediamine)platinum (II) molecule has two possible stereoisomers: cis-dichloro(ethylenediamine)platinum (II) or trans-dichloro(ethylenediamine)platinum (II). The cis form is more active than the trans form, but both are equally effective in inhibiting DNA synthesis. Dichloro(ethylenediamine)platinum (II) also reacts with chloride ions to form an ion pair complex that is taken up by cells. This complex disrupts cell metabolism and leads to apoptosis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 326.08 g/mol
• Formula: C₂H₆N₂PtCl₂
• Purity: Min. 95%