2'-O-tert-Butyldimethylsilyl-5'-O-tritylthymidine 3'-CE phosphoramidite
Ref. 3D-PB08947
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Product Information
- 2'-O-tert-Butyldimethylsilyl-5'-O-trityl-D-thymidine 3'-CE phosphoramidite
2'-O-tert-Butyldimethylsilyl-5'-O-tritylthymidine 3'-CE phosphoramidite is a novel monophosphate derivative that is used as an activator for DNA synthesis. This compound is synthesized by reacting 2,4,6-triisopropylbenzenesilyl chloride with 5'-O-tritylthymidine 3'-hydroxyl in the presence of a base. The resulting intermediate is then converted to the desired product with 1,1'-carbonyldiimidazole and 2-(N,N-dimethylamino)ethoxychloroformate.
2'-O-tert-Butyldimethylsilyl-5'-O-tritylthymidine 3'-CE phosphoramidite has been shown to be effective against hepatitis B virus and herpes simplex virus type 1 (HSV1).
Chemical properties
Technical inquiry about: 3D-PB08947 2'-O-tert-Butyldimethylsilyl-5'-O-tritylthymidine 3'-CE phosphoramidite
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