CRF (Ovine)

CAS: 9015-71-8

Ref. 3D-PCR-4111-S

Product Information

• Name: CRF (Ovine)
• Synonyms: Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser- Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2 Corticotropin-Releasing Factor (Ovine), ACTH - releasing factor, ACTH-releasing hormone, CRF, CRF (hormone), CRH, Corticoliberin, Corticotrophin-releasing hormone, Corticotropin-Releasing Hormone, Corticotropin-releasing activity, Corticotropin-releasing hormone-41, Crf (Ovine), Crf-41
• CAS: 9015-71-8

Description

Corticotropin Releasing Factor (CRF) is a peptide hormone involved in the regulation of the neuroendocrine system, the hypothalamic-pituitary-adrenal (HPA) axis. The hypothalamus releases CRF during stress and in turn CRF stimulates the production of stress hormones such as glucocorticoids and adrenocorticotropin (ACTH). A negative feedback loop is created as glucocorticoids then prevents further endocrine activity exhibited by the pituitary gland and hypothalamus. Interestingly in patients with depression, it has been found that the hypothalamic-pituitary adrenal axis is over stimulated thus increased production of CRF occurs resulting in depression symptoms. Furthermore studies have shown the expression of CRF receptors in glial cells and T-cells and elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments.
This product is available as a 0.1mg vial.

• Brand: Biosynth

Chemical properties

• Molecular weight: 4,670.3 g/mol
• Formula: C₂₀₅H₃₃₉N₅₉O₆₃S
• Purity: Min. 95%