5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite
Ref. 3D-PD46115
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Product Information
- 5'-O-DMT-2'-O-TOM-N2-methylguanosine 3'-CE phosphoramidite
5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite is a novel monophosphate nucleotide analog of guanosine, which has been modified to include an additional methyl group on the 2' position. It exhibits antiviral activity and is a potent activator of RNA polymerase II, with a Km of ∼0.05 μM. 5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite is used in the synthesis of ribonucleosides and deoxyribonucleosides for DNA and RNA experiments. The compound has also been shown to be active against some cancers, such as leukemia, breast cancer, prostate cancer, and colon cancer.
5'-O-DMT-2'-O-
Chemical properties
Technical inquiry about: 3D-PD46115 5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite
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