AC480 (BMS-599626)

CAS: 714971-09-2

Ref. 3D-PDB97109

Product Information

• Name: AC480 (BMS-599626)
• Synonyms: (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate, Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, Ac480, (3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
• CAS: 714971-09-2

Description

AC480 is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) that has been shown to produce light emission in a variety of cell lines. When AC480 binds to EGFR, it inhibits its kinase activity, which prevents the receptor from transmitting signals that stimulate cell growth. AC480 has a high degree of selectivity for EGFR over other kinases and has been shown to inhibit tumor growth in animal models. In addition, AC480 enhances radiation-induced cell death in prostate cancer cells. This drug also inhibits the production of antibodies associated with autoimmune diseases and may be used to treat these conditions.

• Brand: Biosynth

Chemical properties

• Molecular weight: 530.55 g/mol
• Formula: C₂₇H₂₇FN₈O₃
• Purity: Min. 95%