![[D-Arg1,D-Trp7,9,Leu11]-Substance P](https://static.cymitquimica.com/products/3D/img/PSP-4173.png "Click to enlarge")
[D-Arg1,D-Trp7,9,Leu11]-Substance P
Ref. 3D-PSP-4173
| 25mg | 1,237.00 € |
Product Information
- D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 • 3HCl • 8H2OSpantide
This product is a Substance P antagonist. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.
Chemical properties
Technical inquiry about: 3D-PSP-4173 [D-Arg1,D-Trp7,9,Leu11]-Substance P
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