COG 133 Trifluoroacetate salt
CAS: 514200-66-9
Ref. 3D-PVA20066
| 5mg | 1,152.00 € | ||
| 10mg | 1,602.00 € | ||
| 25mg | 3,003.00 € | ||
| 50mg | 4,805.00 € |
Product Information
- LRVRLASHLRKLRKRLL apoE(133-149) ApoE peptide fragment
COG 133 is a conjugate of the nicotinic acetylcholine receptor agonist, nicotine, and an amyloid protein. The COG 133 analog was found to be effective in animal models of inflammatory bowel disease (IBD). COG 133 has been shown to reduce the production of TNF-α and other inflammatory cytokines in vitro and in vivo. This analog also contains a region that encompasses the active site of the nicotinic acetylcholine receptor, which may account for its efficacy. COG 133 inhibits inflammation by binding with high affinity to the nicotinic acetylcholine receptors on macrophages, leading to decreased production of pro-inflammatory cytokines such as TNF-α and IL-6.
Chemical properties
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