Incyclinide

CAS: 15866-90-7

Ref. 3D-QAA86690

Product Information

• Name: Incyclinide
• Synonyms: (4aS,5aR,12aS)-1,4,4a,5,5a,6,11,12a-Octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4aS,5aR,12aS)-, 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, [4aS-(4aα,5aα,12aα)]-, 4-De(dimethylamino)-6-demethyl-6-deoxytetracycline, 4-De(dimethylamino)sancycline, Cmt 3, Cmt-3，Col-3，Nsc-683551, Col 3, Metastat, NSC 683551

Description

Incyclinide is a novel, synthetic, cell permeable, small-molecule antibiotic that exhibits high antibacterial efficacy and has been shown to kill cancer cells. This compound has demonstrated inhibitory properties on the activity of matrix metalloproteinases such as MMP-9. Incyclinide also inhibits the production of proinflammatory cytokines such as TNF-α and IL-1β in human monocytes.
The pharmacokinetics of incyclinide have been studied in humans. The drug is rapidly absorbed with a bioavailability of 100% and reaches peak plasma concentrations within 1 hour after administration. It is excreted unchanged in urine, mainly through glomerular filtration, with an elimination half life of 8 hours.

• Brand: Biosynth

Chemical properties

• Molecular weight: 371.34 g/mol
• Formula: C₁₉H₁₇NO₇
• Purity: Min. 95%