Product Information
- Ag 957
- Nsc654705
- Tyrphostin AG 957
Tyrphostin AG957 is a small molecule that inhibits the Bcr-Abl kinase, which is involved in the uncontrolled growth of white blood cells and cancer cells. Tyrphostin AG957 binds to the basic region of bcr-abl kinase, preventing its autophosphorylation. This inhibition prevents the activation of downstream targets such as myeloid cell leukemia sequence 1 (Mcl-1) and integrin receptors, which are vital for cell proliferation and survival. Tyrphostin AG957 has also been shown to decrease oxidative injury in mitochondrial membrane potentials in K562 cells.
Chemical properties
Technical inquiry about: 3D-QFA67476 Tyrphostin AG957
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