Ethyl 2-chloro-6-methylpyrimidine-4-carboxylate
CAS: 265328-14-1
Ref. 3D-QKA32814
| 1g | 728.00 € | ||
| 100mg | 183.00 € |
Product Information
Ethyl 2-chloro-6-methylpyrimidine-4-carboxylate (EMPC) is a fluorinated pyrimidine analog that is an agonist of the nuclear factor kappa B (NF-κB). EMPC inhibits the transcriptional activity of NF-κB by binding to its inhibitor, IkappaB. This binding prevents the phosphorylation and degradation of IkappaB. EMPC also has an oral bioavailability, which is mediated by its chlorine substitution. This drug has been shown to have anti-inflammatory effects in vitro and in vivo, as well as increased intestinal permeability in vitro.
EMPC is used for medicinal purposes because it can be used to inhibit the production of inflammatory mediators such as prostaglandin E2 and nitric oxide synthase.
Chemical properties
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