Product Information
- (2R)-3-ammonio-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonate
- (2S)-3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
- 2-Hydroxy-saclofen
- 2-OH-Saclofen
- 3-Amino-2-(4-Chlorophenyl)-2-Hydroxypropane-1-Sulfonic Acid
- 3-Amino-2-(4-chlorophenyl)-2-hydroxypropylsulfonic acid
- Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-
- Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-
- beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid
- β-(Aminomethyl)-4-chloro-β-hydroxybenzeneethanesulfonic acid
- See more synonyms
2-Hydroxysaclofen is a cholinergic agent that is structurally related to baclofen. It has been shown to have antinociceptive and locomotor-stimulating effects in mice, which may be due to its ability to bind to the 5-HT2 receptors. This drug also blocks the neurotransmitter glutamate at NMDA receptors in the spinal cord and brainstem, which may also contribute to its analgesic effects. 2-Hydroxysaclofen has been shown to produce a dose-dependent sedative effect in rats, with sedation occurring at doses of 0.1 mg/kg or higher. It also inhibits dopamine release from striatal synaptosomes, indicating inhibition of dopamine uptake by presynaptic neurons.
Chemical properties
Technical inquiry about: 3D-SEA35464 2-Hydroxysaclofen
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