2-Hydroxysaclofen

CAS: 117354-64-0

Ref. 3D-SEA35464

Product Information

• Name: 2-Hydroxysaclofen
• Synonyms: (2R)-3-ammonio-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonate, (2S)-3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid, 2-Hydroxy-saclofen, 2-OH-Saclofen, 3-Amino-2-(4-Chlorophenyl)-2-Hydroxypropane-1-Sulfonic Acid, 3-Amino-2-(4-chlorophenyl)-2-hydroxypropylsulfonic acid, Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy-, Benzeneethanesulfonic acid, β-(aminomethyl)-4-chloro-β-hydroxy-, beta-(Aminomethyl)-4-chloro-beta-hydroxybenzeneethanesulfonic acid, β-(Aminomethyl)-4-chloro-β-hydroxybenzeneethanesulfonic acid

Description

2-Hydroxysaclofen is a cholinergic agent that is structurally related to baclofen. It has been shown to have antinociceptive and locomotor-stimulating effects in mice, which may be due to its ability to bind to the 5-HT2 receptors. This drug also blocks the neurotransmitter glutamate at NMDA receptors in the spinal cord and brainstem, which may also contribute to its analgesic effects. 2-Hydroxysaclofen has been shown to produce a dose-dependent sedative effect in rats, with sedation occurring at doses of 0.1 mg/kg or higher. It also inhibits dopamine release from striatal synaptosomes, indicating inhibition of dopamine uptake by presynaptic neurons.

• Brand: Biosynth

Chemical properties

• Molecular weight: 265.71 g/mol
• Formula: C₉H₁₂ClNO₄S
• Purity: Min. 95%