2-Chloro-4-cyanobenzoic acid
CAS: 117738-77-9
Ref. 3D-SEA73877
| 1g | Discontinued | ||
| 5g | Discontinued | ||
| 100mg | Discontinued | ||
| 250mg | Discontinued | ||
| 500mg | Discontinued |
Product Information
2-Chloro-4-cyanobenzoic acid is an electron receptor antagonist that binds to the androgen receptor. It has been shown to be a potent androgen receptor antagonist in vitro and in vivo, with a synergistic effect when combined with other androgen receptor antagonists. This antagonistic activity may be due to the substitution of adamantyl residues in the ligand binding domain of the androgen receptor. 2-Chloro-4-cyanobenzoic acid has also been shown to have an antiestrogenic effect by blocking estrogen receptors. Molecular modeling studies suggest a number of ways for 2-chloro-4-cyanobenzoic acid to bind to the androgen receptor, including docking on top of helix 12 or 17, or through hydrogen bonding with polar groups such as serine residue 587.
