Product Information
2-Chloro-4-cyanobenzoic acid is an electron receptor antagonist that binds to the androgen receptor. It has been shown to be a potent androgen receptor antagonist in vitro and in vivo, with a synergistic effect when combined with other androgen receptor antagonists. This antagonistic activity may be due to the substitution of adamantyl residues in the ligand binding domain of the androgen receptor. 2-Chloro-4-cyanobenzoic acid has also been shown to have an antiestrogenic effect by blocking estrogen receptors. Molecular modeling studies suggest a number of ways for 2-chloro-4-cyanobenzoic acid to bind to the androgen receptor, including docking on top of helix 12 or 17, or through hydrogen bonding with polar groups such as serine residue 587.
Chemical properties
Technical inquiry about: 3D-SEA73877 2-Chloro-4-cyanobenzoic acid
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