Product Information
Ruxolitinib is a small molecule that inhibits the activity of PD-1, which is a protein that regulates immune responses. Ruxolitinib has been shown to be effective against myelofibrosis and other diseases that are characterized by cellular dedifferentiation, such as chronic graft versus host disease. It also inhibits the production of proteins involved in tumor growth and progression. Ruxolitinib binds to PD-L1, an inhibitory receptor on T cells, and blocks the interaction between PD-L1 and its ligands, preventing T cell activation. The binding of ruxolitinib with PD-L1 can induce receptor internalization or activate downstream signalling pathways for apoptosis.
Chemical properties
Technical inquiry about: 3D-STB93916 Ruxolitinib sulfate
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