1,2,3,4-Tetra-O-acetyl-beta-D-glucuronic acid methyl ester

CAS: 7355-18-2

Ref. 3D-T-1700

Product Information

• Name: 1,2,3,4-Tetra-O-acetyl-beta-D-glucuronic acid methyl ester
• Synonyms: beta-D-Glucopyranuronic acid, methyl ester, tetraacetate, (2S,3S,4S,5R,6S)-methyl 3,4,5,6-tetraacetoxy-tetrahydro-2H-pyran-2-carboxylate, 1,2,3,4-Tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranuronic acid methyl ester, Glucopyranuronic acid, methyl ester, tetraacetate, β-<span class="text-smallcaps">D</span>-, Methyl 1,2,3,4-Tetra-O-Acetyl-Beta-D-Glucuronate, Methyl 1,2,3,4-tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranuronate, Methyl O-tetraacetyl-beta-D-glucopyranuronate, Methyl tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranuronate, NSC 16925, NSC 82042, beta-D-Glucopyranuronic acid, methyl ester, tetraacetate, methyl 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranuronate, methyl 1,2,3,4-tetra-O-acetylhexopyranuronate, β-<span class="text-smallcaps">D</span>-Glucopyranuronic acid, methyl ester, 1,2,3,4-tetraacetate, β-<span class="text-smallcaps">D</span>-Glucopyranuronic acid, methyl ester, tetraacetate
• CAS: 7355-18-2

Description

1,2,3,4-Tetra-O-acetyl-beta-D-glucuronic acid methyl ester is a phosphatidylinositol (PtdIns) synthesis inhibitor. It inhibits the activation of the PtdIns 3 kinase enzyme by binding to its C2 domain. This inhibitor blocks the synthesis of PtdIns 3,4,5P3 and reduces the activity of protein kinases such as Akt and PKC. The structural analysis of this compound has been done on wild type virus and mouse tumor cells in vitro. One study showed that 1,2,3,4-Tetra-O-acetyl-beta-D-glucuronic acid methyl ester can inhibit hematopoietic progenitor cells and suppress wild type virus growth in vivo.1,2,3,4 Tetra-O-acetyl beta D glucuronic acid methyl ester may have potential as

• Brand: Biosynth

Chemical properties

• Molecular weight: 376.32 g/mol
• Formula: C₁₅H₂₀O₁₁