Product Information
- 3-Amino-5-amino-1H-indazole
- 1H-Indazole, 3,5-diamino-
1H-Indazole-3,5-diamine is a ligand that binds to the active site of the enzyme nitric oxide synthase. The binding of 1H-indazole-3,5-diamine inhibits the conversion of arginine to citrulline and disrupts the interaction between the enzyme and its cofactors. This leads to decreased production of nitric oxide. 1H-Indazole-3,5-diamine has been shown to cause cancer cell death in vitro by inhibiting DNA synthesis and increasing levels of reactive oxygen species. It also inhibits cancer cell growth in vivo by causing apoptosis and necrosis.
Chemical properties
Technical inquiry about: 3D-UAA33514 1H-Indazole-3,5-diamine
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