Product Information
3-Benzyloxolane-2,5-dione is a biodegradable compound that has been used as a radiation sensitizer in cancer therapy. It is a prodrug that is converted to 3-benzyloxyacrylic acid (3BA) by enzymatic oxidation. 3BA undergoes an intramolecular nucleophilic substitution reaction to form the benzylideneketal, which can then react with an electron donor such as chloride or maleate. This produces an aromatic hydrocarbon and an alcohol, which can be metabolized by various enzymes. The benzylidene ketal reacts with DNA bases covalently and forms crosslinks between DNA strands, resulting in cell death. It has also been shown to have antifungal properties against Candida albicans.
Chemical properties
Technical inquiry about: 3D-UAA54443 3-Benzyloxolane-2,5-dione
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