Product Information
- 3,4-Dihydroxyphenylhydroxamic acid
- Benzamide, N,3,4-trihydroxy-
- N,3,4-Trihydroxybenzamide
- Nsc-324360
- Vf 147
Didox is a low-potency, orally active, non-nitrogenous nucleoside analog that is metabolized to its active form. It is used in cancer chemotherapy to treat leukemia and solid cancers. Didox has been shown to be a potent inhibitor of reductase in mouse tumor cells, which may be due to its inhibition of ribonucleotide reductase. This inhibition leads to the accumulation of ribonucleotides and subsequent depletion of deoxyribonucleotides, which are essential for DNA synthesis and cell division. Didox has also been shown to have minimal toxicity as it does not cross the blood-brain barrier or accumulate in the liver.
Chemical properties
Technical inquiry about: 3D-UCA83983 Didox
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