Bis(1,3-dibutylbarbituric acid) trimethine oxonol
CAS: 70363-83-6
Ref. 3D-VCA36383
5mg | Discontinued | ||
10mg | Discontinued | ||
25mg | Discontinued | ||
50mg | Discontinued | ||
100mg | Discontinued |
Product Information
- 1,3-Dibutyl-5-(3-(1,3-dibutyl-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidinyl)-2-propenylidene)-2,4,6(1H,3H,5H)pyrimidinetrione
- Neurodye DiBAC4(3)
Bis(1,3-dibutylbarbituric acid) trimethine oxonol is a cationic dye that can be used to stain and detect the presence of anionic lipids. It has been shown to bind to the anionic lipid head groups in bilayers, which may be due to its ability to introduce positive charge into the bilayer. This binding induces changes in the cell membrane structure and leads to cell death. Bis(1,3-dibutylbarbituric acid) trimethine oxonol has also been shown to inhibit ion channels by acting as a cation (positively charged). This inhibition of ion channels leads to increased permeability and depolarization of the membrane, resulting in cell death.