4-Aminopyrimidine-2-carbonitrile
CAS: 245321-46-4
Ref. 3D-VJA32146
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Product Information
- 2-Pyrimidinecarbonitrile, 4-amino- (9CI)
- 4-Aminopyrimidine-2-Carbonitrile
4-Aminopyrimidine-2-carbonitrile is an organic compound that is structurally related to pyrimidine derivatives. It is a drug candidate for the treatment of tuberculosis (TB) and other multidrug resistant bacteria. 4-Aminopyrimidine-2-carbonitrile has been shown to be more potent than formamide and triethyl orthoformate, but less potent than aminopyrazole. The mechanism of action of 4-aminopyrimidine-2-carbonitrile is not well understood, but it may involve an epoxide intermediate that generates reactive oxygen species, which causes necrosis in the bacterial cell. The drug also exhibits some activity against tumour necrosis factor alpha (TNFα).
Chemical properties
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